The Biomarker for Chronic Inflammation
The suPAR test is the first in the USA proven to accurately measure chronic inflammation, delivering actionable insights that can significantly impact your health outcomes.
Easy Test Process
Blood Sample
A healthcare professional will safely collect a blood sample and securely send it to our laboratory for analysis.
Laboratory Analysis
Your sample undergoes a detailed analysis to accurately measure
the level of suPAR present
in the blood.
Get the Results
Results will be available in your profile within 7 business days after analysis for you to share with your healthcare practitioner.
What Does the suPAR Test Measure?
The suPAR test measures the levels of soluble urokinase plasminogen activator receptor (suPAR) in the blood, a biomarker of chronic inflammation.
Indicator of Immune Activation:
Elevated suPAR levels may indicate the presence of chronic low-grade inflammation, which is associated with increased risk of morbidity and mortality from chronic diseases.
Chronic Inflammation:
Systemic chronic inflammation is a persistent, low-grade inflammatory state that plays a major role in the development and progression of many chronic diseases
Stable Biomarker:
Unlike acute inflammation markers (such as CRP) that spike with infections or injuries and quickly return to normal, suPAR provides a stable measure of your underlying chronic inflammatory state.
Lifestyle Influences:
suPAR levels are responsive to lifestyle factors, such as diet and exercise, and can serve as an early warning sign for health deterioration.
How to
Read the Results
Green suPAR score: low chronic inflammation
Yellow suPAR score: moderate chronic inflammation
Orange suPAR score: elevated chronic inflammation
Red suPAR score: significantly elevated chronic inflammation
Regardless of the test result, you'll gain meaningful insights into your health status, enabling you to adjust your lifestyle accordingly.
This test is not intended to diagnose, treat, cure, or prevent any specific disease or condition. suPAR is a non-specific marker of inflammation and may be elevated in various conditions, including serious acute infections, chronic diseases, and other inflammatory states. Results should be interpreted by a qualified healthcare provider in conjunction with clinical history, symptoms, and other laboratory findings.
Understanding InflammAGE
InflammAGE refers to the complex biological process where chronic inflammation accelerates the aging process and contributes to age-related diseases.
This phenomenon links systemic chronic inflammation to various chronic diseases and is crucial for developing strategies that mitigate these risks and promote healthier aging.
How suPAR Tests Compare to Other Biomarker Tests?
Unlike other biomarkers, such as cholesterol, insulin, and glucose, that typically capture acute reactions or are specific to certain diseases, suPAR provides a more systemic perspective of an individual's chronic inflammation.
Furthermore, suPAR remains stable in the bloodstream, offering consistent and reliable readings, which is crucial for tracking changes over time and assessing the impact of interventions.
FAQs
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No. The suPAR test has been validated under CLIA regulations for Laboratory Developed Tests (LDTs), but it has not been cleared or approved by the U.S. Food and Drug Administration.
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Yes, the suPAR test is backed by extensive scientific research. For a detailed look at the supporting scientific papers, please visit our Scientific Research page to learn more about how the test has been developed and validated.
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suPAR is a modifiable biomarker that responds to lifestyle interventions:
Smoking Cessation: Quitting smoking can decrease suPAR levels within 4 weeks. Daily smokers have higher suPAR levels compared to non-smoker.
Physical Activity: Regular exercise is associated with lower suPAR levels. Low physical activity is associated with higher suPAR levels
Diet: A healthier diet is associated with lower suPAR levels. An unhealthy diet is associated with higher suPAR levels
Weight Management: Higher body mass index is associated with elevated suPAR.
Exercise: Inactive individuals can lower their suPAR by up to 0.4 ng/ml through exercise and training. Individuals with a BMI over 35 can lower their level by up to 0.5 ng/ml by losing weight.
Diet: You can lower your suPAR by up to 0.3 ng/ml by eating a healthy and varied diet.4Fagerberg, B., Borné, Y., Barregard, L., Sallsten, G., Forsgard, N., Hedblad, B., Persson, M., & Engström, G. (2017). Cadmium exposure is associated with soluble urokinase plasminogen activator receptor, a circulating marker of inflammation and future cardiovascular disease. Environmental research, 152, 185-191.
Sleep: Research suggests that you can lower your suPAR by ensuring you get enough sleep and optimizing your sleep quality.
Stress management: If you are stressed, you can reduce your suPAR by 0.3 ng/ml through stress management. This can be achieved through breathing exercises, meditation, forest bathing, or exercise.
Reduce alcohol intake: Excessive alcohol intake causes inflammation in the body and can therefore increase your suPAR level. The relationship between moderate alcohol consumption and suPAR is still being investigated, but research suggests that minimal alcohol intake can reduce your suPAR.
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suPAR levels naturally increase with age in healthy individuals. Your Biological Age Index represents the chronological age at which your measured suPAR level is typical among healthy individuals of your sex.
A Biological Age higher than your chronological age may indicate accelerated biological aging associated with elevated chronic inflammation.
This calculation is based on reference data from 9,303 healthy Danish blood donors aged 18-65 years
Sex-adjusted reference ranges are provided because women generally have slightly higher suPAR levels than men.